Ndere Island is a small island (4.2 km or 1.6 sq. mi) in Winam Gulf of Lake Victoria in Kenya. It was gazetted as the Ndere Island National Reserve in November 1986 and has since that time been uninhabited.

Ndere means "meeting place" in Dholuo. According to Luo folklore, early tribal migrants rested up near Ndere after their long journey south up the Nile River Valley. They found the lush shoreline so pleasing that they stayed.

Notable fauna associated with the island include African fish eagles, swifts, hippopotamus, and Nile crocodiles. About fifty impalas have been introduced to the island.

The Waseges flows through regions of intensive coffee cultivation where heavy use is made of chemical fertilizers and pesticides, which may be polluting the lake. Many visitors are attracted to the hot springs on the western lakeshore, and these cause pollution from solid wastes. Siltation is another threat to biodiversity.